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Apigenin

Apiin and Apigenin Glycosides from Parsley: Parsley Extract (Petroselinum Crispum (Parsley) Extract) from Aqueous AVE Extraction

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With our Parsley Extract (INCI: Petroselinum Crispum (Parsley) Extract), we offer a purely aqueous plant extract from Petroselinum crispum, available in three carrier variants: Glycerin, Pentylene Glycol and Propylene Glycol. The extract is of conventional quality and, according to the CDS, suitable for vegans. For formulators, the clearly documented marker profile is of particular interest. The data sheet lists apiin as the primary marker, names apigenin and apigenin glycosides as further compounds and defines a narrowly scoped antioxidant claim framework. The Glycerin variant is also suitable for food, making the extract attractive for companies serving both cosmetics and food from a single raw material source.

Apiin as primary marker: the key figures from the CDS

Apiin is at the heart of the marker profile. The CDS states a calculated content of 0.2 to 1.1 mg/g for the finished product. Important for interpretation: this is explicitly a semi-quantitative estimate based on limited data ("Limited data, semi-quantitative estimate") and not an analytical standardization. As a reference, the CDS draws on literature values for the herbal drug, which report an apiin content of 1 to 4 % in the dried leaf (Justesen and Knuthsen 2001; Slimestad et al. 2020).

In addition to apiin, the CDS lists apigenin as a characteristic constituent and assigns it the function "Soothing", i.e. a calming cosmetic function. The data sheet also states that apigenin glycosides transfer into the aqueous extract. For concept development, this results in a consistent picture: the extract reflects the hydrophilic constituent spectrum of parsley, with apiin as the documented key parameter.

Aqueous extraction: why myristicin and apiol do not end up in the extract

The extract is obtained with purified water as the extraction solvent using our AVE technology (Adaptive Vacuum Extraction). The drug-to-extract ratio (DER) is 1:10, and the extract content in the product is approx. 30 %. Mathematically, 1 kg of CONIUNCTA® extract therefore contains the hydrophilic constituents of approx. 30 g of dried plant parts, regardless of the chosen carrier variant. The CAS number is 84012-33-9.

The choice of an aqueous process shapes the constituent spectrum. Although the CDS documents myristicin and apiol for parsley, it explicitly states that both remain in the essential oil and do not transfer into the aqueous extract. The extract should therefore not be understood as a carrier of the plant's essential oil fraction, but as an extract of its water-soluble components. For fragrance allergens according to Annex III, the CDS indicates the status "Not derivable", meaning no statement can be derived from the available data. Our technical team will clarify questions regarding declaration in the final product individually.

Antioxidant care and skin conditioning: the substantiated claim framework

For cosmetics, the CDS names "Antioxidant protection" as the supported claim area and describes the cosmetic effect as "Skin conditioning, antioxidant". This allows Parsley Extract to be positioned as an antioxidant and skin-conditioning component in care concepts. Since all three variants are hydrophilic liquid extracts, water-based formats are the obvious platform.

Equally important is what the data sheet does not cover. The target area "General skin health" mentioned in the CDS is explicitly marked as mechanistic background and not as a product claim. Likewise, the "Soothing" function is assigned to the constituent apigenin and is not formulated as a claim for the extract as a whole. Substantiation of advertising claims for the final product is the responsibility of the responsible person under Regulation (EC) 1223/2009 (Art. 4 and Art. 20) and Regulation (EU) 655/2013. This clear separation between substantiated claim and background information facilitates regulatory-compliant communication.

Glycerin, Pentylene Glycol or Propylene Glycol: three carriers compared directly

All three variants contain approx. 30 % extract but differ in the standardization medium and thus in the INCI declaration. The global INCI lists the plant component as Petroselinum Crispum (Parsley) Extract in each case, the EU INCI as Petroselinum Crispum Extract:

  • Glycerin: approx. 70 % anhydrous glycerin (≥ 99.5 %) and approx. 30 % extract content. EU INCI: Glycerin, Petroselinum Crispum Extract. Suitable for cosmetics and, as the only variant, also for food.
  • Pentylene Glycol: approx. 50 % water, approx. 30 % extract, approx. 20 % pentylene glycol. EU INCI: Aqua, Pentylene Glycol, Petroselinum Crispum Extract. Suitable for cosmetics.
  • Propylene Glycol: approx. 40 % water, approx. 30 % extract, approx. 30 % propylene glycol. EU INCI: Aqua, Propylene Glycol, Petroselinum Crispum Extract. Suitable for cosmetics, not food-grade according to the TDS.

In practice, the existing formulation often determines the variant. Anyone wishing to declare a concept without additional glycols or planning a parallel food application will choose the Glycerin variant. Further extracts on this carrier base can be found in our collection of Glycerin extracts. If a formula already contains pentylene glycol or propylene glycol, the matching variant avoids an additional solvent appearing in the INCI list. The TDS specifies a cosmetic use concentration of 2 to 5 % for all variants. For orientation, the CDS provides an example calculation: at 3.5 % use, the formulation contains 7.4 to 37.8 µg/g apiin. Our technical team will answer specific formulation and dosage questions.

Parsley in food: exclusively the Glycerin variant

According to the CDS, only the Glycerin variant is intended for the food industry. The CDS describes the effect in the food sector as "Traditional dietary ingredient" and names functional foods and beverages at 0.5 to 2 % as the application area, indicated in the TDS as a literature value. For a use level of 1.25 %, the CDS calculates 2.6 to 13.5 µg/g apiin in the formulation.

For labeling, the SDS states: allergen labeling under Regulation (EU) 1169/2011 is the responsibility of the food business operator. The vegan suitability documented in the CDS facilitates integration into plant-based product lines. Efficacy claims for a final food product cannot be derived from the data sheet; positioning therefore remains with parsley as an ingredient.

Safety data, storage and documentation at a glance

According to the SDS, Parsley Extract is not a hazardous substance and is not classified under CLP (EC 1272/2008): pictogram, signal word and H and P statements do not apply. All carrier variants are assigned to WGK 1 (slightly hazardous to water), and it is not dangerous goods within the meaning of ADR/RID, IMDG and IATA. REACH registration is not applicable, as it is a mixture and the extract is exempt under Annex V No. 8. For handling, the SDS specifies safety glasses according to EN 166; skin protection is not required. The storage class is 12 (non-combustible liquids according to TRGS 510); flash point determination according to EN ISO 2719 is still pending according to the SDS.

The TDS recommends dry storage at 10 to 30 °C in the original sealed container, giving a shelf life of 24 months. The SDS specifies 15 to 25 °C for storage of tightly sealed containers. Temperature-dependent color changes may occur during storage; if turbidity or precipitation occurs, filtration is required, which does not affect quality. Values for pH and relative density are provided in the CoA. We provide TDS, SDS and CDS via our technical documentation. Our category classic plant extracts offers an overview of the entire range. All specifications and carrier variants in detail: View Parsley Extract in the CONIUNCTA® shop.

CONIUNCTA®: Raw materials, data and services for future-ready formulations.